HCID 178480615, compound → HCID 178480614, compound

Participants

Reaction Steps

The procedure used in Example 6 is followed, starting from 1.95 g of 4-[5-fluoro-6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-9H-fluoren-9-one oxime (Z,E), obtained in the previous stage, and 285 mg of Raney nickel in 40 ml of ethanol and 40 ml of tetrahydrofuran for 16 hours at 60° C. under an initial hydrogen pressure of one bar. After filtration of the catalyst, concentration to dryness under reduced pressure and purification by formation of a paste with diisopropyl ether, in this way we obtain 1.7 g of 4-[5-fluoro-6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-9H-fluoren-9(R,S)-ylamine, in the form of an orange powder, which is used as it is in the following stage, with the following characteristics:

Provenance & Evidence