Water → HCID 178514936, compound

Participants

Reaction Conditions

Reaction Steps

The procedure used in stage 1 of Example 230 is followed. In a 50 ml round-bottomed flask under argon, dissolve 1.07 g of 4-(5-fluoro-6-methoxy-1H-benzimidazol-2-yl)-9H-fluoren-9-one, obtained in stage 3 of Example 268, in 20 ml of dichloromethane, cooled to 0° C. and add 7.8 ml of a molar solution of boron tribromide in dichloromethane. After stirring for 20 hours, the reaction mixture is poured into water, and the insoluble material is drained, washed with water and then dried. After purification by formation of a paste with diisopropyl ether, in this way we obtain 914 mg of 4-(5-fluoro-6-hydroxy-1H-benzimidazol-2-yl)-9H-fluoren-9-one, in the form of a brown powder, which is used as it is in the following stage, with the following characteristics:

Provenance & Evidence