HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → Imatinib
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 4-(Chloromethyl)-N-(4-methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)phenyl)benzamide | HCID 10181075 | — |
| Product | Imatinib | HCID 5291 | — |
Reaction Steps
In certain embodiments of the invention, after condensing 4-chloromethyl-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide with an excess of N-methylpiperazine to obtain imatinib base, and adding water or a mixture of water and an organic solvent; the reaction mixture is neutralized.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07674901B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-f96c09414e354ccfb02bd3f011bfd8d8 |
| Source note | uspto-grants-2010_03 |