Diethylamine → HCID 23332767, compound

Participants

Reaction Steps

Four grams (0.0123 mole) of the compound of Example 27, 3.81 ml (0.0369 mole) of diethylamine and 80 ml of dimethylformamide were heated at 80° C. for 6 hours. After evaporating the solvent, the reaction mass was taken up with chloroform, and the obtained organic solution was first washed with a saturated aqueous solution of sodium carbonate and then with water (twice). After drying over sodium sulfate, the chloroform was evaporated off and the obtained residue was passed through a silica-gel column by eluting with chloroform:methanol=99:1 (by volume). The obtained product was finally dissolved in diethyl ether and treated with a saturated solution of hydrogen chloride in diethyl ether whereby the title compound crystallized out. Yield 3.7 g. (76%). M.p. 252°-56° C.

Provenance & Evidence