N-bromobutanimide → HCID 12535975, compound

Participants

Reaction Steps

Alternatively, the starting material II may be prepared by reacting 2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one (prepared as disclosed by Krapcho et al, J. Med. Chem., 6, 544 (1963)) with N-bromosuccinimide to form 3-bromo-2-phenyl-1,5-benzothiazepin-4(5H)-one which is then reacted with cuprous cyanide in the presence of a solvent such as dimethylformamide to form the 1,2-dihydro-2-oxo-4-phenyl-3-quinolinecarbonitrile starting material.

Provenance & Evidence