HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-Amino-3-chlorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 4-Amino-3-chlorobenzoate | HCID 1515284 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Amino-3-chlorobenzoic acid | HCID 17211 | 92% |
Reaction Steps
4-Amino-3-chloro-benzoic acid methyl ester (21.6 mmol) was saponified in EtOH (25 ml) and NaOH (1M, 25 ml) at reflux for 2 h. The organic solvent was evaporated and pH adjusted to 4. The product was removed by filtration, washed with water and dried in vacuo to give 4-amino-3-chloro-benzoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07674912B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-7effaf629b434d4097ff4af1eb87b6e2 |
| Source note | uspto-grants-2010_03 |