Pyridine → HCID 16122819, compound

HRID 2243444Notes

Reaction equation

HRID 2243444 reaction equation
[NH2:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([NH:8][C:9]2[S:10][CH:11]=[CH:12][N:13]=2)=[O:7])=[CH:4][C:3]=1[O:16][CH3:17].N1C=CC=CC=1.[CH3:24][C:25]([CH3:31])([CH3:30])[CH2:26][C:27](Cl)=[O:28]>ClCCCl.CN(C=O)C>[CH3:24][C:25]([CH3:31])([CH3:30])[CH2:26][C:27]([NH:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([NH:8][C:9]2[S:10][CH:11]=[CH:12][N:13]=2)=[O:7])=[CH:4][C:3]=1[O:16][CH3:17])=[O:28]

Participants

5

Reactant 3

HCID 1049PyridineHCID 815143,3-Dimethylbutanoyl chlorideHCID 86047098HCID 86047098, compound2×

Product 1

HCID 16122819HCID 16122819, compound

Reagents, catalysts & solvents 1

HCID 20184825Dce dmfSolvent

Procedure

To 200 μL of a 0.2 M stock solution of 4-amino-3-methoxy-N-thiazol-2-yl-benzamide in 1,2-dichloroethane/DMF, containing 1.2 mmol pyridine per mmol 4-amino-3-methoxy-N-thiazol-2-yl-benzamide, was added 0.05 mmol of 3,3-dimethyl-butyric acid chloride. The reaction mixture was incubated at ambient temperature for 2 h. Purification was performed by preparative HPLC-MS.

Workup

  1. customPurification

Sources & evidence

ORD record
ord-b5dd0606bf0f4df19936384460beb4f4
Source dataset
uspto-grants-2010_03
Patent number
US07674912B2

Reaction notes

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