HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glutaric anhydride → 4-[(4-Ethynylphenyl)carbamoyl]butanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glutaric anhydride | HCID 7940 | — |
| Reactant | 4-Ethynylaniline | HCID 3760025 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-[(4-Ethynylphenyl)carbamoyl]butanoic acid | HCID 24826477 | — |
Reaction Steps
To a solution of 4-ethynylaniline (0.99 g, 8.5 mmol) in CH2Cl2 (100 ml) is added glutaric anhydride (1.06 g, 9.30 mmol). After 1 h, the resulting slurry is concentrated by rotary evaporation and the crude mixture is purified by silica column chromatography (10% methanol/5% TEA/CH2Cl2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07674924B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-98518cd5c54c4e6c97898ba1c6732705 |
| Source note | uspto-grants-2010_03 |