6-Amino-1-hexanol → HCID 24826555, compound

HRID 2243457Notes

Reaction equation

HRID 2243457 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:24])[CH2:11][CH2:12][CH2:13][C:14]([O:16]N2C(=O)CCC2=O)=O)=[CH:5][CH:4]=1)#[CH:2].[NH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][OH:32]>C(Cl)Cl>[OH:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][NH:25][C:14](=[O:16])[CH2:13][CH2:12][CH2:11][C:10]([NH:9][C:6]1[CH:5]=[CH:4][C:3]([C:1]#[CH:2])=[CH:8][CH:7]=1)=[O:24]

Participants

4

Reactant 2

HCID 199606-Amino-1-hexanolHCID 86619218HCID 86619218, compound

Product 1

HCID 24826555HCID 24826555, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of (2,5-dioxopyrrolidin-1-yl) 5-(4-ethynylphenyl)amino-5-oxo-pentanate (0.2 g, 0.6 mmol) in CH2Cl2 (10 ml) is added slowly to a solution of 1-amino-6-hexanol (0.35 g, 3.0 mmol) in CH2Cl2 (50 ml) with vigorous stirring. The crude reaction solution is concentrated by rotary evaporation and the mixture is purified by silica column chromatography (10% methanol/5% TEA/CH2Cl2).

Workup

  1. customThe crude reaction solution
  2. concentrationis concentrated by rotary evaporation
  3. customthe mixture is purified by silica column chromatography (10% methanol/5% TEA/CH2Cl2)

Sources & evidence

ORD record
ord-453c724507ec4198b9f3d6d08e491a03
Source dataset
uspto-grants-2010_03
Patent number
US07674924B2

Reaction notes

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