HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 45119472, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Acetic Anhydride | HCID 7918 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 45119472 | HCID 45119472 | — |
Reaction Steps
Subsequent 1-N-acetylation of the compounds of formula III-a-b can be carried out using standard conditions. In a typical experiment, compounds of formula III-a-b are heated under reflux in acetic anhydride or reacted in a solvent such as dichloromethane, tetrahydrofuran, toluene or pyridine with acetyl chloride in the presence of a base such as N,N-diisopropylethylamine, triethylamine or sodium hydride to give the 1-N-acetyl-4-methyl-1,2-dihydroquinoline derivatives of formula IV-a-b.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07674909B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-f80714434d4a4d9aacad3d5890ca3fc6 |
| Source note | uspto-grants-2010_03 |