Water → HCID 68540610, compound

Participants

Reaction Steps

Sodium tert-butoxide (360 mg, 3.7 mmol, 3.3 equiv) was added to a solution of methyl thioglycolate (0.110 ml, 1.23 mmol, 1.1 equiv) in DMF (10 ml). 2-chloro-benzo[b]thiophene-3-carboxylic acid methyl ester (235 mg, 1.12 mmol, 1 equiv, available from Maybridge) was then added and the mixture became orange. When no starting material was observed by TLC, water was added followed by extraction with EtOAc. Purification by column chromatography yielded 162 mg (61%) of 1-hydroxy-3,8-dithia-cyclopenta[a]indene-2-carboxylic acid methyl ester as an orange solid.

Provenance & Evidence