Acetic Acid → HCID 68547570, compound

Participants

Reaction Steps

Sodium triacetoxyborohydride (90 mg, 0.42 mmol, 2.5 equiv) was added to a mixture of 1-ethoxycarbonylmethoxy-2-methoxycarbonyl-3,8-dithia-cyclopenta[a]inden-6-yl-ammonium trifluoroacetate (82 mg, 0.17 mmol), benzaldehyde (21 mg, 0.2 mmol, 1.2 equiv), and acetic acid (5wl) in DCE (4 ml). The reaction mixture was stirred at RT for 16 hr then DCM (20 ml) was added. The mixture was washed with sat. NaHCO3, dried over MgSO4, filtered, and the solvent was removed in vacuo. Purification by column chromatography yielded 61 mg (81%) of 6-benzylamino-1-ethoxycarbonylmethoxy-3,8-dithia-cyclopenta[a]indene-2-carboxylic acid methyl ester.

Provenance & Evidence