Trifluoromethanesulfonic anhydride → HCID 87491673, compound

Participants

Reaction Steps

To a solution of 3-hydroxy-benzo[b]thiophene-2,6-dicarboxylic acid 6-allyl ester 2-methyl ester (3.2 g, 10.95 mmol) in DCM (50 mL) was added TEA (1.83 mL, 13.14 mmol), Tf2O (2.2 mL, 13.14 mL) and DMAP (67 mg, 0.55 mmol) at 0° C. The temperature was allowed to rise to room temperature and the resultant mixture was stirred for 4 hours, washed with aq. NaHCO3 and dried over MgSO4. The crude product was purified on CombiFlash column eluted with hexanes/EtOAc to give desire product, 3-trifluoromethanesulfonyloxy-benzo[b]thiophene-2,6-dicarboxylic acid 6-allyl ester 2-methyl ester as a white solid (3.88g, 84%).

Provenance & Evidence