反应详情

A 1M solution of boron tribromide in dichloromethane (5 ml, 5 mmol) was added to an ice water cooled solution of 8-(4-methoxyphenyl)octylbromide (1.5 g, 5 mmol) in dichloromethane (10 ml). After 4 hours at room temperature, water was added and the dichloromethane separated, washed with water, dried over anhydrous magnesium sulphate, and evaporated to give an oil, which was chromatographed over flash silica, eluting with chloroform, followed by 2% methanol in chloroform to give 8-(4-hydroxyphenyl)octylbromide as an oil (MS: M+ =284).

1. customthe dichloromethane separated
2. washwashed with water
3. dry with materialdried over anhydrous magnesium sulphate
4. customevaporated
5. customto give an oil, which
6. customwas chromatographed over flash silica
7. washeluting with chloroform