Acetyl chloride → HCID 68544240, compound

HRID 2243503Notes

Reaction equation

[C:1](Cl)(=[O:3])[CH3:2].[CH3:5][O:6][C:7]([C:9]1[S:28][C:12]2[C:13]3[CH:14]=[CH:15][CH:16]=[C:17]([NH:20][CH2:21][CH:22]4[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]4)[C:18]=3[S:19][C:11]=2[C:10]=1[O:29][CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32])=[O:8]>>[CH3:5][O:6][C:7]([C:9]1[S:28][C:12]2[C:13]3[CH:14]=[CH:15][CH:16]=[C:17]([N:20]([C:1](=[O:3])[CH3:2])[CH2:21][CH:22]4[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]4)[C:18]=3[S:19][C:11]=2[C:10]=1[O:29][CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32])=[O:8]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 68548829HCID 68548829, compound

Product 1

HCID 68544240HCID 68544240, compoundYield 58%

Procedure

Step B Amide Formation: Addition of acetyl chloride (0.05 mL, 0.65 mmol) to 7-(Cyclohexylmethyl-amino)-1-ethoxycarbonylmethoxy-3,8-dithia-cyclopenta[a]indene-2-carboxylic acid methyl ester (60 mg, 0.13 mmol) was carried out following a procedure similar to that delineated in Step B, Example 27, affording 38 mg of 7-(Acetyl-cyclohexylmethyl-amino)-1-ethoxycarbonylmethoxy-3,8-dithia-cyclopenta[a]indene-2-carboxylic acid methyl ester as a yellow solid. (58% yield).

Sources & evidence

ORD record: ord-f6a135775aba411a80bb0f92ae81d95f
Source dataset: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07674822B2

Reaction notes

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