HCID 21827382, compound → HCID 23332791, compound

HRID 224351Notes

Reaction equation

HRID 224351 reaction equation
ClC1C=CC2N3C(=O)C(C(OCC)=O)=CN=C3SC=2C=1.[SH:21][C:22]1[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:23]=1[N:29]1[C:34](=O)[C:33]([C:36]([OH:38])=[O:37])=[CH:32][NH:31][C:30]1=[O:39]>>[Cl:28][C:26]1[CH:25]=[CH:24][C:23]2[N:29]3[C:30](=[O:39])[N:31]=[CH:32][C:33]([C:36]([OH:38])=[O:37])=[C:34]3[S:21][C:22]=2[CH:27]=1

Participants

3

Reactant 2

HCID 21827382HCID 21827382, compoundHCID 23332800HCID 23332800, compound

Product 1

HCID 23332791HCID 23332791, compoundYield 60%

Procedure

from ethyl 8-chloro-4-oxo-4H-pyrimido[2,1-b]benzthiazole-3-carboxylate, via 1-(2-mercapto-4-chlorophenyl)-5-carboxypyrimidine-2,6-dione, 7-chloro-1-oxo-1H-pyrimido-[6,1-b]benzthiazole-4-carboxylic acid (yield 60% of theory; m.p. 264°-265° C.).

Sources & evidence

ORD record
ord-747658de5c274da3ba455541a6f68bee
Source dataset
uspto-grants-1980_11
Patent number
US04232024

Reaction notes

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