Sodium Carbonate → HCID 86737313, compound

Participants

Reaction Steps

A solution of 3,14-dimethoxy-8α,17-dimethyl-4,5α-epoxymorphinan-6-one (2) (0.89 g, 2.59 mmol) in a mixture of 25 milliliters CHCl3 /25 milliliters CH2Cl2 was treated with anhydrous Na2CO3 (1.6 g, 15.09 mmol), followed by cyanogen bromide (1.6 g, 15.10 mmol). The reaction mixture was refluxed overnight with stirring while being kept under a nitrogen atmosphere. The sodium carbonate was removed by filtration and the filtrate concentrated under reduced pressure to give 0.89 g (97%) of the title compound as a brownish solid. The product, which showed only a single spot on tlc, was used without further purification.

Provenance & Evidence