Thionyl Chloride → HCID 86619101, compound

Participants

Reaction Conditions

Reaction Steps

Under a nitrogen atmosphere, about 5 g (about 13.075 mmol, about 1 eq) coumarin-oxyhexylbenzoic acid (compound 3) was put into about 100 ml of methylene chloride, and about 1.71 g of thionylchloride (about 14.383 mmol, about 1.1 eq) was added thereto, and the mixture was then stirred at about 35° C. for about 5 hours to form a reaction solution. Subsequently, a solvent was removed from the reaction solution, and then the residual was recrystallized using ethylacetate/hexane to obtain coumarin-oxyhexylbenzoyl chloride (compound 4).

Provenance & Evidence