Ethyl isocyanate → HCID 11703962, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 11 (22 mg, 0.068 mmol, 1.0 equiv) in THF (2 mL) was added 4-(Dimethylamino)pyridine (1 mg, 0.008 mmol, 0.1 equiv) and ethyl isocyanate (53 μL, 0.675 mmol, 10.0 equiv). After heating at 50° C. for 2 hrs, the solvent was removed in vacuo. The resulting yellow residue was purified by silica gel chromatography (5% MeOH:CH2Cl2) to afford urea 12a. MS (MH+) 398.4; Calculated 397.2 for C23H19N5O2.

Provenance & Evidence