4-Amino-2,2,6,6-tetramethylpiperidine → Ammonium Hydroxide

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Reaction Steps

The compound 3-[8-(2,6-difluorophenyl)-2-(methylsulfonyl)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl]-4-methyl-N-(phenylmethyl)benzamide, (0.056 g, 0.1 mmol) was dissolved in THF (5 mL) and 4-amino-2,2,6,6-tetramethylpiperidine (0.032 g, 0.2 mmol) was added. The mixture was stirred under argon at room temperature for 17 h. The solvents were pumped off in vacuo. The residue was flash chromatographed on silica gel (15 g) eluted with 6:0.5:0.05, to 6:1:0.1, CH2Cl2:isopropanol:NH4OH to give the title compound as a white amorphous solid. mp (dec) 160-165° C.; LC-MS m/z 640 (M+H)+, 1.62 min (ret. time).

Provenance & Evidence