HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hypofluorous acid, trifluoromethyl ester → 3-fluoro-7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hypofluorous acid, trifluoromethyl ester | HCID 78989 | — |
| Reactant | Dirazepic acid | HCID 23332610 | — |
| Reactant | 3-fluoro-5-o-chlorophenyl-7-chloro-2,3-dihydro-1H-1,4-benzodiazepin-2-one-3-carboxylic acid | HCID 23332687 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3-fluoro-7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one | HCID 13125993 | — |
Reaction Steps
3.7 g. of 3-fluoro-5-o-chlorophenyl-7-chloro-2,3-dihydro-1H-1,4-benzodiazepin-2-one-3-carboxylic acid, obtainable from 5-o-chlorophenyl-7-chloro-2,3-dihydro-1H-1,4-benzodiazepin-2-one-3-carboxylic acid and CF3OF, in 50 ml. of pyridine are boiled for 1 hour with 0.5 g. of CuO. The mixture is cooled, poured onto ice and filtered to give 3-fluoro-5-o-chlorophenyl-7-chloro-2,3-dihydro-1H-1,4-benzodiazepin-2-one, m.p. 211° (decomposition).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04232016 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-3354ae5334104c5188fa9d11bfab739d |
| Source note | uspto-grants-1980_11 |