HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 7-Chloro-3-fluoro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2-Amino-5-chlorobenzophenone | HCID 12870 | — |
| Reactant | 2-(alpha-Bromo-alpha-fluoroacetamido)-5-chlorobenzophenone | HCID 23332597 | — |
| Reactant | alpha-Bromo-alpha-fluoroacetyl bromide | HCID 23332663 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 7-Chloro-3-fluoro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one | HCID 13125987 | — |
Reaction Steps
A solution of 3.71 g. of 2-(α-bromo-α-fluoro-acetamido)-5-chlorobenzophenone, obtainable from 2-amino-5-chlorobenzophenone and α-bromo-α-fluoroacetyl bromide, in 100 ml. of ether and 60 ml. of 13% methanolic NH3 is allowed to stand for 18 hours at 20° and is evaporated. Working up in the customary manner, using water/methylene chloride, gives 3-fluoro-5-phenyl-7-chloro-2,3-dihydro-1H-1,4-benzodiazepin-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04232016 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-3be39c3562a64b79b714987da623365c |
| Source note | uspto-grants-1980_11 |