HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 7-Chloro-3-fluoro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2-(alpha-Bromo-alpha-fluoroacetamido)-5-chlorobenzophenone | HCID 23332597 | — |
| Reactant | 2-(alpha-Amino-alpha-fluoroacetamido)-5-chlorobenzophenone | HCID 23332701 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 7-Chloro-3-fluoro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one | HCID 13125987 | — |
Reaction Steps
A solution of 3.07 g. of 2-(α-amino-α-fluoroacetamido)-5-chlorobenzophenone, obtainable from 2-(α-bromo-α-fluoroacetamido)-5-chlorobenzophenone and liquid NH3, in 35 ml. of pyridine is boiled for 2 hours and evaporated. Working up in the customary manner gives 3-fluoro-5-phenyl-7-chloro-2,3-dihydro-1H-1,4-benzodiazepin-2-one, m.p. 235° (decomposition).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04232016 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-3252695280144913a9261ccc2e671eb9 |
| Source note | uspto-grants-1980_11 |