Boron trifluoride → HCID 23332648, compound

Participants

Reaction Steps

A solution of 0.8 g. of NO2F in 13 ml. of sulfolane is saturated with BF3 at 5°-10°. This solution is added dropwise to a stirred solution of 3.03 g. of 1-methyl-3-fluoro-5-o-chlorophenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one, obtainable from the corresponding 3-chloro compound and AgF, in 15 ml. of sulfolane at 10°-15°. The mixture is stirred for 1 hour more at 15°-25° and worked up in the customary manner to give 1-methyl-3-fluoro-5-o-chlorophenyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one.

Provenance & Evidence