HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Nitrophenylboronic Acid → 3-Aminophenylboronic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Nitrophenylboronic Acid | HCID 1677 | — |
| Reactant | Magnesium | HCID 5462224 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Aminophenylboronic acid | HCID 92269 | — |
Reaction Steps
A mixture of 1-bromonaphthalene 1, magnesium powder in THF is irradiated for 15 min to produce Grignard reagent 2 which reacts with tributyl borate to yield the boronic ester 3. Hydrolysis of 3 with aqueous sulfuric acid affords 1-naphthalene boronic acid 4 (Song, Y; Ding, Z; Wang, Q; Tao, F. Syn. Comm. 1998, 28, 3757, WO 9964428).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07678158B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-26a71592cce244debe8a5b62487bfc96 |
| Source note | uspto-grants-2010_03 |