Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | Methyl 6-([1,1'-biphenyl]-4-yl)hexanoate | HCID 54145223 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-(Biphenyl-4-yl)hexanol | HCID 10658623 | — |
Reaction Steps
6-(Biphenyl-4-yl)hexanoic acid methyl ester (0.67 g, 2.4 mmol) in THF (5 ml) was added dropwise to lithium aluminium hydride (0.2 g, 5.3 mmol) in THF cooled to 0° C. After stirring for 1 day at room temperature, water (1 ml) then 5M sodium hydroxide (1 ml) followed by water (2 ml) were added cautiously followed by stirring at room temperature for 2 hours. The precipitate was filtered off and filtrate was evaporated to give 6-(biphenyl-4-yl)hexanol as a solid (MS: M+ =254).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05428065 |
|---|
| Source dataset | uspto-grants-1995_06 |
|---|
| ORD ID | ord-3469efc0c0bd4d1ea64b690e5edfb6e0 |
|---|
| Source note | uspto-grants-1995_06 |
|---|
