Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | 1-Azabicyclo(2.2.2)octan-3-one, hydrochloride (1:1) | HCID 102019 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | sodium;acetate;trihydrate | HCID 178476686 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Quinuclidinone oxime | HCID 297408 | 107% |
Reaction Steps
32.33 g (200 mmol) of 3-Quinuclidinone hydrochloride was dissolved in 75 ml of water, and to the solution of hydroxylamine hydrochloride (16.4 g; 236 mmol) and CH3CO2Na.3H2O (80 g; 588 mmol) was added. The mixture was stirred at 70° C. for 1 hour. Then NaCl (10 g) was dissolved in the mixture and was cooled to 0° C. Separated crystals were filtered and carefully dried. The obtained crude 3-quinuclidone oxime (approx. 30 g) was used in the next step of the synthesis without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07678788B2 |
|---|
| Source dataset | uspto-grants-2010_03 |
|---|
| ORD ID | ord-4efd74f2ec094c0d89af2753a073bbfa |
|---|
| Source note | uspto-grants-2010_03 |
|---|
