Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Amino-3,5-dichlorobenzylamine | HCID 18975763 | — |
| Reactant | tert-Butyl 7-(4-(allyloxy)phenyl)-5-oxo-9-oxa-2-thia-4,8-diazaundec-7-en-3-ylidenecarbamate | HCID 72531903 | — |
| Product | HCID 178474352 | HCID 178474352 | — |
Reaction Steps
A solution of tert-butyl 7-(4-(allyloxy)phenyl)-5-oxo-9-oxa-2-thia-4,8-diazaundec-7-en-3-ylidenecarbamate from Step D (1.14 g) in THF (4 mL) was added 4-(aminomethyl)-2,6-dichloroaniline (647 mg) and diisopropylethylamine (0.46 mL), and the resulting mixture was heated at 58° C. for 12 h. The solvents were removed in vacuo, and the residue was purified by Biotage eluting with 10-25% ethyl acetate/90-75% hexanes to give the title compound as a yellowish oil (1.28 g). retention time: 2.37 min (method A). MS (ESI) (M+H)+ 578.23.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07678784B2 |
|---|
| Source dataset | uspto-grants-2010_03 |
|---|
| ORD ID | ord-9948d7209db54573a003fb4b488fe3c3 |
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| Source note | uspto-grants-2010_03 |
|---|
