HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 1-tert-Butyl 2-methyl (2R)-piperidine-1,2-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (2R)-1-[(tert-butoxy)carbonyl]piperidine-2-carboxylic acid | HCID 688618 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-tert-Butyl 2-methyl (2R)-piperidine-1,2-dicarboxylate | HCID 45072456 | 100% |
Reaction Steps
To (R)-Piperidine-1,2-dicarboxylic acid 1-tert-butyl ester (5.1 g, 22.2 mmol) in DMF (60 mL) were added K2CO3 (12.3 g, 88.8 mmol) and MeI (1.7 mL, 26.6 mmol). After stirring at room temperature overnight, the reaction mixture was diluted with ethyl acetate. The organic layer washed with water (6 times) and brine, dried over anhydrous Na2SO4, filtered and concentrated to give the title product (5.4 g, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07678796B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-94535433c2ef4737a94e2a08d86ae0e4 |
| Source note | uspto-grants-2010_03 |