Dimethylformamide dimethyl acetal → HCID 59006708, compound

Participants

Role	Name	HCID	Charge
Reactant	Dimethylformamide dimethyl acetal	HCID 78373	—
Reactant	Methyl 6-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate	HCID 14117784	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 59006708	HCID 59006708	49%

Reaction Conditions

Temperature	60 °C

Reaction Steps

A suspension of the title compound of Example 33.1 (0.80 g, 4.8 mmol) and dimethylformamide dimethylacetal (3.2 mL, 24 mmol) in DMF (10 mL) was heated at 60° C. for 48 hours. The reaction mixture was concentrated and the residue was dissolved in dichloromethane and washed with water. The organic layer was concentrated. Recrystallization from ethyl acetate/heptane afforded the title compound (423 mg, 49%)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07678796B2
Source dataset	uspto-grants-2010_03
ORD ID	ord-51d03a101718429a991bcceffa9515e9
Source note	uspto-grants-2010_03