Hydrochloric Acid → Ziprasidone Hydrochloride

Participants

Reaction Steps

To a slurry of ziprasidone base Form B (10 g) in monochlorobenzene (100 ml) was added aqueous HCl (37%) (10 ml) at room temperature and the stirring was continued at room temperature over night. A sticky solid was formed, to which methanol (50 ml) was added, followed by stirring for an additional 4 hours. The solid was filtered and washed with methanol. The wet product was crystalline ziprasidone HCl as confirmed by XRD. After drying at 50° C. for about 16 hours, crystalline ziprasidone HCl Form A was obtained (10.37 g) as confirmed by XRD (The water content was 4.17% by K.F.).

Provenance & Evidence