1,4-Dioxane → HCID 86620098, compound

Participants

Reaction Steps

To a mixture of 1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5-piperazin-1-yl-4-[(trifluoromethyl)sulfonyl]-1H-pyrazole-3-carbonitrile (0.40 g, 0.8 mmol) and diisopropylethylamin (0.13 g, 1.0 mmol) in dioxane (5 mL) benzylbromide (0.14 g, 0.8 mmol) was added and refluxed for 5 h. Extractive workup (heptane-ethyl acetate, water) and chromatography gave the title product (Compound 01-45, 0.31 g) as an oil; 1H-NMR: 2.30(4H), 3.19 (4H), 3.45 (2H), 7.25 (5H), 7.82 (2H); 19F-NMR: −64.1 (PhCF3); −79.6 ppm (SO2CF3).

Provenance & Evidence