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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2243975Generated: November 1, 2026

Hydrazine hydrate (1:1) → 3-(4-Fluoro-2-trifluoromethyl-phenyl)-6,6-dimethyl-6,7-dihydro-5H-cyclopenta[c]pyridazine

https://huagongshe.com/reaction/2243975

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrazine hydrate (1:1)HCID 24654—
Reactant4,4-Dimethylcyclopentane-1,2-dioneHCID 14289654—
Reactant[2-(4-Fluoro-2-trifluoromethyl-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl esterHCID 86609939—
Product3-(4-Fluoro-2-trifluoromethyl-phenyl)-6,6-dimethyl-6,7-dihydro-5H-cyclopenta[c]pyridazineHCID 16063748—

Reaction Steps

light yellow oil. MS (ESI): 311.0 (MH+). Prepared from 4,4-dimethyl-cyclopentane-1,2-dione, [2-(4-Fluoro-2-trifluoromethyl-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester, hydrazine monohydrate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07678795B2
Source datasetuspto-grants-2010_03
ORD IDord-0d764d9495014c68bba73b3987758d7d
Source noteuspto-grants-2010_03