HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → Methyl 4-fluoro-3-nitrobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-Fluoro-3-nitrobenzoic acid | HCID 67987 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 4-fluoro-3-nitrobenzoate | HCID 5219721 | — |
Reaction Steps
Heat a solution of 4-fluoro-3-nitro-benzoic acid (5.00 g, 27.0 mmol, Sigma Chemical Co.) in methanol (135 mL, 0.2M) at reflux and slowly add oxalyl chloride (6.86 g, 54.0 mmol, Aldrich Chemical Co.) through reflux condenser. Stir for 2 h at reflux. Concentrate reaction mixture in vacuo. The title compound solidifies upon standing (5.30 g, 26.6 mmol, 99%): 19F NMR (acetone-d6, 400 MHz) δ-121.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07678794B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-8a92caef84bb4f19b144a4f9f57f8daf |
| Source note | uspto-grants-2010_03 |