Sodium hydride → HCID 68431311, compound

Participants

Reaction Steps

Add 1-(2,4-dihydroxy-3-propyl-phenyl)-ethanone (2.77 g, 14.2 mmol) to sodium hydride (396 mg, 15.7 mmol) in dimethylformamide (20 mL) at 0° C., stir 10 minutes, add 4-bromomethyl-N-(3-cyano-phenyl)-benzenesulfonamide (2.50 g, 7.12 mmol) in dimethylformamide (15 mL) drop wise via addition funnel. After 2 hours at ambient temperature, pour into brine (40 mL), extract with ethyl acetate (2×40 mL), dry organic phase over sodium sulfate, filter and concentrate under reduced pressure. Purify residue by flash chromatography to yield the title compound (1.17 g, 2.52 mmol): MS (m/z): 463 (M−1).

Provenance & Evidence