Tin dichloride dihydrate → HCID 68634976, compound

Participants

Reaction Steps

4-(5-Methyl-2-nitro-phenyl)-piperazine-1-carboxylic acid benzyl ester (5.60 g; 15.7 mmol) and SnCl2.H2O (17.5 g; 77.6 mmol) were refluxed in 100 mL ethanol for 2½ hours. Ethanol was removed in vacuo. The residue was poured into 300 mL saturated NaHCO3. The mixture was extracted with ethyl acetate (2×250 mL). The organic phase was washed with brine (2×100 mL), dried with MgSO4, filtered through a pad of silica and concentrated in vacuo to give 4.71 g (14.5 mmol; 91.6%) 4-(2-amino-5-methyl-phenyl)-piperazine-1-carboxylic acid benzyl ester.

Provenance & Evidence