HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2244045Generated: October 31, 2026
Hydrochloric Acid → 3-(2-piperazin-1-yl-phenylsulfanyl)-1H-indole
https://huagongshe.com/reaction/2244045
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 68635546 | HCID 68635546 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-(2-piperazin-1-yl-phenylsulfanyl)-1H-indole | HCID 11515108 | — |
Reaction Steps
3 M HCl-gas in dry ethyl acetate (3 mL) was added to 3-[2-(4-tert-butoxycarbonyl-piperazin-1-yl)-phenylsulfanyl]-indole-1-carboxylic acid tert-butyl ester. The solution was stirred for 1 h at 0° C. and evaporated under vacuum. The crude product was purified by preparative LC-MS. The isolated product was submitted for testing as DMSO solution.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07678800B2 |
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| Source dataset | uspto-grants-2010_03 |
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| ORD ID | ord-83f69ff359324e74aae984f6af3e3109 |
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| Source note | uspto-grants-2010_03 |
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