Hydrochloric Acid → HCID 25059694, compound

Participants

Reaction Steps

To the solution of 1-amino-6-fluoro-isoquinoline-4-carbonitrile (3 g, 1 eq) in toluene (100 mL) is added 3M MeMgBr in ether (53 mL, 10 eq) at 0° C., then the mixture is stirred at RT for 2 h, then refluxed overnight. The reaction is cooled down and acidified by 2 N HCl aq. to pH˜3, then neutralized by Sat'd NaHCO3 aq (300 mL), extracted by dichloromethane (3×150 mL). The organic layer is dried over Na2SO4, filtered, concentrated to give product 1-(1-amino-6-fluoro-isoquinolin-4-yl)-ethanone (0.8 g, 24%). LC/MS m/z=205 [M+H]+.

Provenance & Evidence