Hydrochloric Acid → HCID 25061491, compound

Participants

Reaction Steps

A solution of 1-amino-6-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-indol-1-yl)-isoquinoline-4-carbonitrile (0.15 g, 0.44 mmol) in THF (2 mL) and H2O (2 mL) is treated with concentrated HCl (10 mL). The reaction mixture is microwaved at 150° C. for 1.5 h. The reaction mixture is then treated with 5 M NaOH until pH=8. The crystals formed are collected by vacuum filtration, and dried to afford 0.07 g (44%) of 1-amino-6-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-indol-1-yl)-isoquinoline-4-carboxylic acid. LC/MS m/z=364 [M+H]+, RT=2.12 min.

Provenance & Evidence