HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-Chloro-7-fluoroquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 7-Fluoroquinazolin-4(3H)-one | HCID 135398496 | — |
| Product | 4-Chloro-7-fluoroquinazoline | HCID 16227013 | — |
Reaction Steps
7-Fluoro-3H-quinazolin-4-one (8.2 g, 50 mmol) is heated at reflux in thionyl chloride (80 mL). Concentration affords the expected 4-Chloro-7-fluoro-quinazoline (9.1 g, ˜quant).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07678803B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-fadf7e4e1bc84828bb24083218bb893b |
| Source note | uspto-grants-2010_03 |