HCID 136334106, compound → HCID 136029356, compound

HRID 2244092Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:24]=[CH:23][CH:22]=[CH:21][C:4]=1[C:5]([NH:7][C:8]1[CH:16]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:14]=[CH:13][C:9]=1[C:10]([NH2:12])=[O:11])=O.COC1C=CC=CC=1C1NC(=O)C2C(=CC(C(F)(F)F)=CC=2)N=1>[OH-].[Na+]>[CH3:1][O:2][C:3]1[CH:24]=[CH:23][CH:22]=[CH:21][C:4]=1[C:5]1[NH:12][C:10](=[O:11])[C:9]2[C:8](=[CH:16][C:15]([C:17]([F:20])([F:19])[F:18])=[CH:14][CH:13]=2)[N:7]=1

Participants

Conditions

Temperature: 120 °C

Procedure

2-(2-Methoxy-phenyl)-7-trifluoromethyl-3H-quinazolin-4-one 2-(2-Methoxy-benzoylamino)-4-trifluoromethyl-benzamide (3.8 g, 11.24 mmol) was suspended in 145 ml 5% aqueous NaOH solution then refluxed for three hours at 120° C. The reaction was cooled to room temperature and adjusted to pH 4 causing the desired product to precipitate from solution. Solid was collected by vacuum filtration as a white solid and dried on the lyophilizer for 24 h. White solid 2.7 g, 75% yield. LC/MS (10-99%) M/Z 321.1, retention time 3.25 minutes.

Workup

temperatureThe reaction was cooled to room temperature

Sources & evidence

ORD record: ord-48b9679cdfd34115aaa4b89e674b50ea
Source dataset: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07678802B2

Reaction notes

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