2-(2-(Diethylamino)ethyl)-5-methyl-2H-(1)benzothiopyrano(4,3,2-cd)indazole → 8a-(4-(piperidin-1-yl)benzyl)-2-(4-tert-butylphenylsulfonyl)-1,2,3,4,8,8a-hexahydroisoquinolin-6(7H)-one
Reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([N:14]2[CH2:23][CH2:22][C:21]3[C:16]([CH2:25][C:26]4[CH:31]=[CH:30][C:29](B5OC(C)(C)C(C)(C)O5)=[CH:28][CH:27]=4)([CH2:17][CH2:18][C:19](=[O:24])[CH:20]=3)[CH2:15]2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].CCN(CCN1[N:64]=[C:63]2[C:50]3C(SC4C2=CC=CC=4)=C(C)[CH:53]=[CH:54][C:49]1=3)CC>>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([S:11]([N:14]2[CH2:23][CH2:22][C:21]3[C:16]([CH2:25][C:26]4[CH:27]=[CH:28][C:29]([N:64]5[CH2:53][CH2:54][CH2:49][CH2:50][CH2:63]5)=[CH:30][CH:31]=4)([CH2:17][CH2:18][C:19](=[O:24])[CH:20]=3)[CH2:15]2)(=[O:12])=[O:13])=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]Participants
3
Reactant 2
Product 1
Procedure
The following compounds were similarly prepared from 2-(4-t-Butylbenzenesulfonyl)-8a-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzyl]-1,3,4,7,8,8a-hexahydro-2H-isoquinolin-6-one (IA-5: Y=4-(B(OC(CH3)2C(CH3)2O)):
Sources & evidence
- ORD record
- ord-36ad3073e08d40fd882c0c51304378d6
- Source dataset
- uspto-grants-2010_03
- Patent number
- US07678813B2
Reaction notes
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