4-Chloro-2-pyridinecarbonitrile → 4-(4-Amino-3-fluorophenoxy)picolinonitrile

HRID 2244140Notes

Reaction equation

HRID 2244140 reaction equation
NC1C=C(C=CC=1)O[C:6]1[CH:11]=[CH:10][N:9]=[C:8]([C:12]([NH2:14])=O)[CH:7]=1.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][C:20]=1[F:26].ClC1C=CN=C(C#N)C=1>>[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][C:6]2[CH:11]=[CH:10][N:9]=[C:8]([C:12]#[N:14])[CH:7]=2)=[CH:21][C:20]=1[F:26]

Participants

4

Reactant 3

HCID 6933424-Chloro-2-pyridinecarbonitrileHCID 27359194-Amino-3-fluorophenolHCID 231372294-(3-Aminophenoxy)pyridine-2-carboxamide

Product 1

HCID 551566584-(4-Amino-3-fluorophenoxy)picolinonitrile

Procedure

4-(4-Amino-3-fluorophenoxy) pyridine-2-carbonitrile (2G) was prepared by a method analogous to that described for 4-(3-aminophenoxy) pyridine-2-carboxamide (2C), starting from 4-amino-3-fluorophenol and 4-chloro-2-cyanopyridine, MS ES: 230 (M+H)+, calcd 230, RT=2.85 min.

Sources & evidence

ORD record
ord-abcbb08ae2f542e3ac34bbdff820325b
Source dataset
uspto-grants-2010_03
Patent number
US07678804B2

Reaction notes

Loading…