HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dimethoxybenzoic Acid → 3-Bromo-2,6-dimethoxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dimethoxybenzoic Acid | HCID 15109 | — |
| Reactant | Bromine | HCID 24408 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Bromo-2,6-dimethoxybenzoic acid | HCID 2774744 | — |
Reaction Steps
A solution of 15 ml of bromine (0.3 mol) in 50 ml of chloroform is added dropwise while stirring and cooling in ice to 54.9 g (0.3 mol) of 2,6-dimethoxybenzoic acid in 150 ml of dioxan. The solution is left at room temperature overnight. The solvent is evaporated and the residue recrystallized from aqueous ethanol. Yield: 59.3 g, m.p. 144°-45° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04232037 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-4a69d9981df04110bfcdd27b9a858423 |
| Source note | uspto-grants-1980_11 |