Hydrochloric Acid → Methyl 2-(2-bromophenyl)acetate

Participants

Reaction Steps

A solution of 2-bromophenylacetic acid (10 g, 46 mmol) and 12 M hydrochloric acid (1 mL, 12 mmol) in methanol (100 mL) was heated to reflux for 16 hours. The cooled solution was then quenched with saturated aqueous sodium hydrogen carbonate (50 mL) and concentrated in vacuo to remove methanol. The aqueous phase (ca. 50 mL) was extracted with ethyl acetate (150 mL), and the organic phase washed with water (75 mL) and brine (75 mL), dried over anhydrous magnesium sulfate, and concentrated in vacuo to give the title compound (10.1 g, 96 %) as a clear, colorless oil.

Provenance & Evidence