Ammonia → HCID 15953079, compound

Participants

Reaction Steps

The title compound was prepared in essentially the same manner as Example 68, replacing 4′-{[3-{[(pyridin-3-ylmethyl)amino]carbonyl}-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-yl]carbonyl}-1,1′-biphenyl-2-carboxylic acid with (4′-{[3-{[(pyridin-3-ylmethyl)amino]carbonyl}-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-yl]carbonyl}-1,1′-biphenyl-2-yl)acetic acid of Example 36, and dimethylamine with ammonia. Purification by flash chromatography using a solvent gradient of 2 to 8% methanol in dichloromethane gave the title compound (0.138 g, 58%) as a white solid.

Provenance & Evidence