HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (S)-(-)-2-((3-Bromo-2,6-dimethoxybenzamido)methyl)-1-ethylpyrrolidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Bromo-2,6-dimethoxybenzoic acid | HCID 2774744 | — |
| Reactant | HCID 70527605 | HCID 70527605 | — |
| Solvent | Water | HCID 962 | — |
| Product | (S)-(-)-2-((3-Bromo-2,6-dimethoxybenzamido)methyl)-1-ethylpyrrolidine hydrochloride | HCID 15565708 | — |
Reaction Steps
Using the same method as for compound in Example 14, except of the addition of triethylamine, this compound was prepared from 8.4 g (0.032 mol) of 3-bromo-2,6-dimethoxybenzoic acid, 20 ml of thionyl chloride and 9.0 g (0.032 mol) of (+)-2-(aminomethyl)-1-ethylpyrrolidine d-tartrate. Yield: 7.5 g, m.p. 166°-68° C., [α]D20° =10.7° (0.5% in water).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04232037 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-678e8210f1d94d6c960d9c3da0f045ea |
| Source note | uspto-grants-1980_11 |