Sulfuryl chloride → HCID 12878331, compound

HRID 224428Notes

Reaction equation

HRID 224428 reaction equation
[CH3:1][O:2][C:3](=[O:19])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:7][C:6]=1[O:17][CH3:18].S(Cl)([Cl:23])(=O)=O>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:19])[CH2:4][C:5]1[CH:10]=[C:9]([Cl:23])[C:8]([CH:11]2[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]2)=[CH:7][C:6]=1[O:17][CH3:18]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 12878330HCID 12878330, compound

Product 1

HCID 12878331HCID 12878331, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The (4-cyclohexyl-2-methyoxyphenyl)-acetic acid methylester obtained as above is dissolved in 500 ml of methylene chloride, and 5.5 ml of sulphuryl chloride and 200 mg of silica gel are added. After stirring at 22° for 60 hours, there is substantial evaporation, and the residue is chromatographed on 300 g of silica gel. A homogeneous product is extracted with methylene chloride.

Workup

  1. customevaporation
  2. customthe residue is chromatographed on 300 g of silica gel
  3. extractionA homogeneous product is extracted with methylene chloride

Sources & evidence

ORD record
ord-c229a8c5a05c409f85627446d25ffdc8
Source dataset
uspto-grants-1980_11
Patent number
US04232039

Reaction notes

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