2,2,2-Trichloro-1-{10-[(4-chloro-2-methylphenoxy)acetyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone → 2,2,2-trichloro-1-{10-[(4-chlorophenoxy)acetyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone

HRID 2244290Notes

Reaction equation

HRID 2244290 reaction equation
ClC1C=CC(OCC(N2C3C=CC=CC=3CN3C=CC=C3C2)=O)=CC=1.[Cl:26][C:27]([Cl:57])([Cl:56])[C:28]([C:30]1[N:39]2[C:33]([CH2:34][N:35]([C:44](=[O:55])[CH2:45][O:46][C:47]3[CH:52]=[CH:51][C:50]([Cl:53])=[CH:49][C:48]=3C)[C:36]3[CH:43]=[CH:42][CH:41]=[CH:40][C:37]=3[CH2:38]2)=[CH:32][CH:31]=1)=[O:29]>>[Cl:57][C:27]([Cl:26])([Cl:56])[C:28]([C:30]1[N:39]2[C:33]([CH2:34][N:35]([C:44](=[O:55])[CH2:45][O:46][C:47]3[CH:48]=[CH:49][C:50]([Cl:53])=[CH:51][CH:52]=3)[C:36]3[CH:43]=[CH:42][CH:41]=[CH:40][C:37]=3[CH2:38]2)=[CH:32][CH:31]=1)=[O:29]

Participants

3

Reactant 2

HCID 160392952,2,2-Trichloro-1-{10-[(4-chloro-2-methylphenoxy)acetyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanoneHCID 6868042910-[(4-Chlorophenoxy)acetyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine

Product 1

HCID 160392192,2,2-trichloro-1-{10-[(4-chlorophenoxy)acetyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone

Procedure

The title compound was prepared from 10-[(4-chlorophenoxy)acetyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine of Step A in the same manner as the preparation of 2,2,2-trichloro-1-{10-[(4-chloro-2-methylphenoxy)acetyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone of Example 139, Step C, m.p. 165-167° C.

Sources & evidence

ORD record
ord-340bd2fc1915454887c5c363d533b11d
Source dataset
uspto-grants-2010_03
Patent number
US07678787B2

Reaction notes

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