Acetaldehyde → 946118-80-5

HRID 2244327Notes

Reaction equation

HRID 2244327 reaction equation
[O:1]=O.[F:3][C:4]1([C:7]2[CH:12]=[CH:11]C(C)=[CH:9][CH:8]=2)[CH2:6][CH2:5]1.[CH:14](=[O:16])[CH3:15]>C(O)(=O)C.O.O.O.O.C([O-])(=O)C.[Co+2].C([O-])(=O)C>[F:3][C:4]1([C:7]2[CH:12]=[CH:11][C:15]([C:14]([OH:1])=[O:16])=[CH:9][CH:8]=2)[CH2:6][CH2:5]1

Participants

6

Reactant 3

HCID 177AcetaldehydeHCID 977OxygenHCID 68703601HCID 68703601, compound

Product 1

HCID 66599234946118-80-5Yield 46%

Reagents, catalysts & solvents 2

HCID 61372Cobalt(II) acetate tetrahydrateCatalystHCID 176Acetic AcidSolvent

Procedure

Oxygen was slowly bubbled at 100° C. through a solution of 1-(1-fluoro-cyclopropyl)-4-methyl-benzene (470 mg, 3.13 mmol), cobalt(II)acetate tetrahydrate (117 mg, 0.46 mmol), and acetaldehyde (0.18 mL, 3.1 mmol) in acetic acid (30 mL) over 16 h. After cooling, the reaction mixture was evaporated and the residue triturated in water. The precipitate was collected by filtration to produce the title compound (257 mg, 46%). Light green solid, MS (EI) 180.1 (M+).

Workup

  1. temperatureAfter cooling
  2. customthe reaction mixture was evaporated
  3. customthe residue triturated in water
  4. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-61b79f41742d4eef8ce098b7f76c38d3
Source dataset
uspto-grants-2010_03
Patent number
US07678818B2

Reaction notes

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